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A Phase 1 Adaptive Dose-escalation Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Antitumor Activity of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL)

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Trial Profile

A Phase 1 Adaptive Dose-escalation Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Antitumor Activity of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL)

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Loncastuximab tesirine (Primary)
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; First in man
  • Sponsors ADC Therapeutics

    • Most Recent Events

    • 10 Apr 2021 Results (n=328) characterizing the pharmacokinetics (PK) of the Lonca dosing regimen and evaluate exposure covariates, presented at the 112th Annual Meeting of the American Association for Cancer Research.
    • 10 Apr 2021 Results (n=328) of pooled analysis of NCT02669017 and NCT03589469 assessing efficacy, safety, tolerability, and tolerable doses of Lonca PBD-conjugated Ab in patients with B-cell non-Hodgkin lymphoma, presented at the 112th Annual Meeting of the American Association for Cancer Research.
    • 19 Nov 2020 Results published in the Blood
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