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Safety, Tolerability and Efficacy of PfSPZ Vaccine Administered by Direct Venous Inoculation (DVI) to Healthy Children and Infants 5 Months Through 9 Years of Age Living in an Area of High Malaria Transmission in Western Kenya: Age De-escalation and Dose Escalation and a Double Blind, Randomized Placebo-Controlled Trial for Safety and Efficacy

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Trial Profile

Safety, Tolerability and Efficacy of PfSPZ Vaccine Administered by Direct Venous Inoculation (DVI) to Healthy Children and Infants 5 Months Through 9 Years of Age Living in an Area of High Malaria Transmission in Western Kenya: Age De-escalation and Dose Escalation and a Double Blind, Randomized Placebo-Controlled Trial for Safety and Efficacy

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 14 Dec 2021

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At a glance

  • Drugs Malaria vaccine live attenuated-Sanaria (Primary)
  • Indications Falciparum malaria
  • Focus Adverse reactions; Pharmacodynamics; Therapeutic Use
  • Sponsors Sanaria

    • Most Recent Events

    • 01 Sep 2021 Results assessing safety, immunogenicity and vaccine efficacy after DVI of PfSPZ Vaccine in 5-12-month-old infants in Kenya, published in the Nature Medicine.
    • 19 May 2020 Results published in the Vaccine
    • 26 Sep 2019 Results assessing safety, tolerability and immunogenicity of various dose regimens of PfSPZ Vaccine published in the Clinical Infectious Diseases

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