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An open-label, multicenter, biomarker study to explore the mechanism of action of ocrelizumab and B-cell biology in patients with relapsing multiple sclerosis or primary progressive multiple sclerosis

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Trial Profile

An open-label, multicenter, biomarker study to explore the mechanism of action of ocrelizumab and B-cell biology in patients with relapsing multiple sclerosis or primary progressive multiple sclerosis

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 10 Dec 2024

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At a glance

  • Drugs Ocrelizumab (Primary) ; Diphenhydramine; Methylprednisolone
  • Indications Multiple sclerosis
  • Focus Biomarker; Pharmacodynamics; Registrational
  • Acronyms OBOE
  • Sponsors Genentech; Roche

    • Most Recent Events

    • 02 Mar 2024 Results measuring resolution of glial activation using MR spectroscopy in a longitudinal study presented at the Americas Committee for Treatment and Research in Multiple Sclerosis Forum 2024
    • 13 Oct 2023 Results assessing immunoglobulin levels by enzyme-linked immunosorbent assay using data from 93 pwRMS and 29 pwPPMS patients from this trial presented at the 9th Triennial joint meeting of Americas Committee for Treatment and Research in Multiple Sclerosis and the European Committee for Treatment and Research in Multiple Sclerosis
    • 28 Aug 2023 Status changed from active, no longer recruiting to completed.

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