Trial Profile

A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-022, an Anti-TIM-3 Monoclonal Antibody, in Patients With Advanced Solid Tumors (AMBER)

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 23 Jun 2025

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At a glance

Drugs Cobolimab (Primary) ; Carboplatin; Cisplatin; Docetaxel; Dostarlimab; Encelimab; Nivolumab; Pemetrexed
Indications Colorectal cancer; Liver cancer; Malignant melanoma; Mesothelioma; Non-small cell lung cancer; Peritoneal cancer; Skin cancer; Solid tumours; Squamous cell cancer
Focus Adverse reactions; First in man; Therapeutic Use
Acronyms AMBER
Sponsors GlaxoSmithKline; GSK; TESARO

Most Recent Events

25 Jan 2025 Trial design presented at the 2025 Gastrointestinal Cancers Symposium
18 Jun 2024 Planned number of patients changed from 475 to 447.
18 Jun 2024 Planned number of patients changed from 475 to 447.

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