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A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

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Trial Profile

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Apr 2026

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At a glance

  • Drugs Semaglutide (Primary)
  • Indications Cardiovascular disorders; Type 2 diabetes mellitus
  • Focus Adverse reactions; Registrational
  • Acronyms PIONEER 6; PIONEER6
  • Sponsors Novo Nordisk

Most Recent Events

  • 02 Mar 2026 According to Novo Nordisk media release,based on results from the pooled analysis of SUSTAIN 6, PIONEER 6, FLOW and SOUL trials Health Canada has approved Ozempic (semaglutide injection) to reduce the risk of major adverse cardiovascular (CV) events (CV death,non fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease and chronic kidney disease.
  • 26 Jun 2023 Results using individual-level participant data from LEADER , SUSTAIN 6 and PIONEER 6 , comparing cardiovascular (CV) protective effect of liraglutide vs semaglutide in subjects with type 2 diabetes, presented at the 83rd Annual Scientific Sessions of the American Diabetes Association
  • 01 Apr 2023 Results of pooled post hoc analysis (n=6480 from two studies SUSTAIN 6/PIONEER 6) assessing the effects of semaglutide versus placebo on eGFR decline published in the Kidney International

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