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Phase I/II Dose Escalation and Cohort Expansion of Safety and Tolerability Study of Intratumoral CD40 Agonistic Monoclonal Antibody APX005M in Combination With Systemic Pembrolizumab in Patients With Metastatic Melanoma

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Trial Profile

Phase I/II Dose Escalation and Cohort Expansion of Safety and Tolerability Study of Intratumoral CD40 Agonistic Monoclonal Antibody APX005M in Combination With Systemic Pembrolizumab in Patients With Metastatic Melanoma

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 16 Dec 2024

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At a glance

  • Drugs Pembrolizumab (Primary) ; Sotigalimab (Primary)
  • Indications Malignant melanoma; Skin cancer
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 22 Feb 2024 Planned End Date changed from 30 Apr 2024 to 30 Apr 2025.
    • 22 Feb 2024 Planned primary completion date changed from 30 Apr 2024 to 30 Apr 2025.
    • 23 Sep 2023 Results (n=32)assessing immune changes to therapy in both t umor tissue and blood samples from the CD40 agonist sotigalimab incombination with pembrolizumab in metastatic melanoma trial presented at the CRI-ENCI-AACR: 7th Annual International Cancer, Immunotherapy Conference

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