Trial Profile

A Phase 1 Dose-Escalation Study of AEB1102 (Co-ArgI-PEG) in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Refractory to Hypomethylating Agents

Status: Completed

Phase of Trial: Phase II

Latest Information Update: 21 Aug 2026

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At a glance

Drugs Pegzilarginase (Primary)
Indications Acute myeloid leukaemia; Myelodysplastic syndromes
Focus Adverse reactions
Sponsors Aeglea Biotherapeutics; Immedica; Spyre Therapeutics

Most Recent Events

13 Aug 2026 Actual primary completion date changed from 1 Dec 2017 to 1 Nov 2017.
27 Nov 2023 According to Spyre Therapeutics media release, Aeglea Biotherapeutics has changed its name to Spyre Therapeutics
05 Jun 2018 Results presented at the 54th Annual Meeting of the American Society of Clinical Oncology

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