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A Placebo-Controlled, Dose-Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of ISIS 703802, Targeting ANGPTL3, Administered Subcutaneously to Healthy Volunteers With Elevated Triglycerides and Subjects With Familial Hypercholesterolemia

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Trial Profile

A Placebo-Controlled, Dose-Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of ISIS 703802, Targeting ANGPTL3, Administered Subcutaneously to Healthy Volunteers With Elevated Triglycerides and Subjects With Familial Hypercholesterolemia

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 05 Apr 2022

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At a glance

  • Drugs Vupanorsen (Primary)
  • Indications Hyperlipoproteinaemia type IIa
  • Focus Adverse reactions; First in man; Pharmacodynamics; Pharmacokinetics
  • Sponsors Ionis Pharmaceuticals

    • Most Recent Events

    • 12 Feb 2018 Status changed from recruiting to completed.
    • 24 May 2017 Results published in the New England Journal of Medicine.
    • 15 Nov 2016 According to an Ionis Pharmaceuticals media release, results of interim analysis from the study were presented at the American Heart Association Scientific Sessions.

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