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A Phase 2 Open-label Pilot Study to Evaluate Efficacy, Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

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Trial Profile

A Phase 2 Open-label Pilot Study to Evaluate Efficacy, Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 15 Dec 2022

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At a glance

  • Drugs Mavacamten (Primary)
  • Indications Hypertrophic cardiomyopathy
  • Focus Proof of concept; Therapeutic Use
  • Acronyms PIONEER-HCM
  • Sponsors MyoKardia

    • Most Recent Events

    • 07 Nov 2022 Results of a Pooled Safety Analysis from 5 Clinical Trials (PIONEER-HCM, MAVERICK-HCM, EXPLORER-HCM, PIONEER-OLE, MAVA-LTE) presented at the American Heart Association Scientific Sessions 2022
    • 24 Jun 2019 According to a MyoKardia media release, results of digital substudy of this trial were published in the Nature Partner Journal, Digital Medicine.
    • 24 Jun 2019 Results of digital substudy of this trial were presented in a MyoKardia Media Release.

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