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A Phase 2, Randomized Study of MLN0128 (a Dual TORC1/2 Inhibitor), MLN0128+MLN1117 (a PI3Kα Inhibitor), Weekly Paclitaxel, or the Combination of Weekly Paclitaxel and MLN0128 in Women With Advanced, Recurrent, or Persistent Endometrial Cancer

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Trial Profile

A Phase 2, Randomized Study of MLN0128 (a Dual TORC1/2 Inhibitor), MLN0128+MLN1117 (a PI3Kα Inhibitor), Weekly Paclitaxel, or the Combination of Weekly Paclitaxel and MLN0128 in Women With Advanced, Recurrent, or Persistent Endometrial Cancer

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 18 Oct 2023

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At a glance

  • Drugs Sapanisertib (Primary) ; Serabelisib (Primary) ; Paclitaxel
  • Indications Adenocarcinoma; Carcinoma; Endometrial cancer
  • Focus Therapeutic Use
  • Sponsors Takeda Oncology

    • Most Recent Events

    • 13 Oct 2023 Results assessing sapanisertib (selective dual inhibitor of mTORC1/2) alone, or in combination with paclitaxel or TAK-117 (a selective small molecule inhibitor of PI3K), versus paclitaxel alone in advanced, recurrent, or persistent endometrial cancer published in the Gynecologic Oncology
    • 21 Nov 2020 Planned number of patients changed from 242 to 260.
    • 21 Nov 2020 This trial has been Completed in Spain (Global End Date: 30 Oct 2020), according to European Clinical Trials Database record.
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