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A Phase 1, Open-label, Multiple-probe Drug-drug Interaction Study to Determine the Effect of Rucaparib on Pharmacokinetics of Caffeine, S-Warfarin, Omeprazole, Midazolam, and Digoxin in Patients With Advanced Solid Tumors

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A Phase 1, Open-label, Multiple-probe Drug-drug Interaction Study to Determine the Effect of Rucaparib on Pharmacokinetics of Caffeine, S-Warfarin, Omeprazole, Midazolam, and Digoxin in Patients With Advanced Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 22 Sep 2023

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At a glance

  • Drugs Rucaparib (Primary) ; Caffeine; Digoxin; Midazolam; Omeprazole; Vitamin K; Warfarin
  • Indications Solid tumours
  • Focus Pharmacokinetics
  • Acronyms DDI
  • Sponsors Clovis Oncology [CEASED]; pharmaand GmbH

    • Most Recent Events

    • 06 Jan 2020 Status changed from active, no longer recruiting to completed.
    • 28 May 2019 Planned End Date changed from 1 May 2019 to 1 Jul 2019.
    • 10 Aug 2018 Planned End Date changed from 1 Sep 2018 to 1 May 2019.

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