Patient Inclusion Criteria

1. Gender:Chinese healthy adult volunteers,male or female; 2. Aged between 18 to 50 years, no more than about 10 years old in same group; 3. Weight: more than 50 kg, and body mass index of 19-24; 4. No allergic history, especially no food and drug allergy by requesting; 5. No fainting of injection or blood history; 6. No significant evidence or abnormal finding in medical history, clinical checks, lab results, 12-lead electrocardiograms (ECGs), X-ray film of chest radiography during the screening period; 7. No abnormal finding history in heart, kidney, digestive tract, nervous system, metabolism system and so on; 8. No other drugs during past 4 weeks; 9. No drug dependency and NO smoking and alcohol addiction by requesting; 10. No abdominal pain, diarrhea and other Gastrointestinal symptoms during past 3 weeks; 11. Make sure subjects take effective contraception during the study and 3 months after the study; 12. All subjects understand the study and possible adverse reactions, volunteered to attend this study and sign the informed consent.

Patient Exclusion Criteria

1. Have any significant cardiovascular, hepatic, renal, gastrointestinal, respiratory endocrine and metabolic, hematologic, neurologic, or psychiatric and other diseases; 2. Have history of bronchospasm; 3. Have history of drug abusing by requesting; 4. Have an allergic constitution, or have allergic history on drug,food by requesting; 5.Smoke 5 cigarettes or same amount of tobacco by requesting; 6.Drinking 28 units alcohol everyweek (1 units=285ml beer or 25ml spirits or 1 glass of wine) by requesting or drinking before 48 hours or during the study, or drinking in 24 hours and alcohol test is positive; 7. Taken any drug during the past 4 weeks; 8. Donated blood or loss blood (1 unit or 350ml) during the past 3 months; if blood loss more than 200ml, the subject can be recruited in 60 days after the blood donated /loss; 9. Taken known drug damage on main organs during the past 3 months; 10. Attending on anther clinical study or attended it 3 month before this study; 11. Have abnormal lab results during screening period; 12. hepatitis positive, including hepatitis B surface antigen and anti-HCV antibody; 13. HIV or syphilis positive; 14. HCG test positive (blood HCG or urine HCG); 15. Menstrual,pregnancy or breast-feeding; 16. Subject cannot understand the scheme or cannot communicate or cooperate with researches; 17. Considered not fit to attend this study on other factors.