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A Phase 1-2, Open-Label, Dose-Finding, Proof of Concept, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CX-2009 in Adults With Metastatic or Locally Advanced Unresectable Solid Tumors (PROCLAIM-CX-2009)

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Trial Profile

A Phase 1-2, Open-Label, Dose-Finding, Proof of Concept, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CX-2009 in Adults With Metastatic or Locally Advanced Unresectable Solid Tumors (PROCLAIM-CX-2009)

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 08 Jan 2024

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At a glance

  • Drugs Pacmilimab (Primary) ; Praluzatamab ravtansine (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Carcinoma; Cholangiocarcinoma; Endometrial cancer; Head and neck cancer; HER2 negative breast cancer; Non-small cell lung cancer; Ovarian cancer; Prostate cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer
  • Focus Adverse reactions; First in man; Proof of concept
  • Acronyms PROCLAIM; PROCLAIM-CX-2009
  • Sponsors CytomX Therapeutics

    • Most Recent Events

    • 03 Jan 2024 Status changed from completed to discontinued.
    • 14 Feb 2022 Results published in the Clinical Cancer Research
    • 08 Jan 2021 Status changed from suspended to completed.

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