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A Randomized, Double-blind, Placebo-controlled Multicenter Study of Subcutaneous Secukinumab to Demonstrate Efficacy in the Treatment of Enthesitis at the Achilles Tendon up to 1 Year in Adult Patients With Active Psoriatic Arthritis (PsA) and Axial Spondyloarthritis (axSpA) (ACHILLES)

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A Randomized, Double-blind, Placebo-controlled Multicenter Study of Subcutaneous Secukinumab to Demonstrate Efficacy in the Treatment of Enthesitis at the Achilles Tendon up to 1 Year in Adult Patients With Active Psoriatic Arthritis (PsA) and Axial Spondyloarthritis (axSpA) (ACHILLES)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 31 May 2022

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At a glance

  • Drugs Secukinumab (Primary)
  • Indications Axial spondyloarthritis; Psoriatic arthritis
  • Focus Registrational; Therapeutic Use
  • Acronyms ACHILLES
  • Sponsors Novartis; Novartis Pharmaceuticals

    • Most Recent Events

    • 16 May 2022 Results of post hoc analysis investigating the imaging characteristics and clinically assessing heel enthesitis in spondyloarthritis, published in the Arthritis Research and Therapy
    • 09 Nov 2021 Results of post hoc analysis applying HEMRIS system in blinded and centrally read MRI data of the heel from the ACHILLES trial, presented at the ACR Convergence 2021.
    • 03 Nov 2021 Primary endpoint (Number (%) of Patients With Resolution of Achilles Tendon Enthesitis) has not been met, according to Results published in the Rheumatology.

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