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A randomized phase II study comparing nivolumab with the combination of carboplatin and pemetrexed for epidermal growth factor receptor (EGFR) mutants non-squamous non-small cell lung cancer acquired resistance to EGFR-tyrosine kinase inhibitor from causes other than T790M.(WJOG8515L)

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A randomized phase II study comparing nivolumab with the combination of carboplatin and pemetrexed for epidermal growth factor receptor (EGFR) mutants non-squamous non-small cell lung cancer acquired resistance to EGFR-tyrosine kinase inhibitor from causes other than T790M.(WJOG8515L)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 14 Oct 2024

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At a glance

  • Drugs Nivolumab (Primary) ; Carboplatin; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use

Most Recent Events

  • 30 Aug 2022 Status changed from active, no longer recruiting to completed.
  • 17 Dec 2021 Results published in the Clinical Cancer Research
  • 08 Jun 2021 Results (n=102)assessing comparing nivolumab (NIVO) with carboplatin-pemetrexed (CbPEM) for patients (pts) with EGFR mutation-positive non-small cell lung cancer (NSCLC) who acquire resistance to tyrosine kinase inhibitors (TKIs) not due to a secondary T790M mutation (WJOG8515L)presented at the 57th Annual Meeting of the American Society of Clinical Oncology

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