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A Phase III Randomized, Open Label Trial to Evaluate Dolutegravir Versus Efavirenz 400 mg, Both Combined With Tenofovir Disoproxil Fumarate + Lamivudine for the Initial Management of HIV Infected Adults in Resource-limited Settings

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Trial Profile

A Phase III Randomized, Open Label Trial to Evaluate Dolutegravir Versus Efavirenz 400 mg, Both Combined With Tenofovir Disoproxil Fumarate + Lamivudine for the Initial Management of HIV Infected Adults in Resource-limited Settings

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 20 Oct 2023

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At a glance

  • Drugs Dolutegravir (Primary) ; Lamivudine/tenofovir-disoproxil-fumarate (Primary) ; Efavirenz
  • Indications HIV-1 infections
  • Focus Therapeutic Use
  • Acronyms NAMSAL

    • Most Recent Events

    • 20 Oct 2023 Results of of a wide range of patient-reported outcomes , published in the JAIDS
    • 14 Aug 2023 Results four-year longitudinal analysis of patient-reported outcomes following initiation of dolutegravir- or low-dose efavirenz-based first-line antiretroviral therapy , published in the JAIDS
    • 26 Oct 2022 Results from DolPHIN-2, ADVANCE, NAMSAL and VISEND, comparing rates of virological failure (VF)and re-suppression in four randomised trials of dolutegravir (DTG), efavirenz (EFV) and protease inhibitors , presented at the 16th International Congress on Drug Therapy and HIV Infection
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