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A Phase I, Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK3326595 in Subjects With Solid Tumors and Non-Hodgkin's Lymphoma

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Trial Profile

A Phase I, Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK3326595 in Subjects With Solid Tumors and Non-Hodgkin's Lymphoma

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 12 Mar 2025

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At a glance

  • Drugs Pemrametostat (Primary)
  • Indications Adenocarcinoma; Adenoid cystic carcinoma; Advanced breast cancer; Bladder cancer; Carcinoma; Colorectal cancer; Glioblastoma; Head and neck cancer; Male breast cancer; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Renal cell carcinoma; Solid tumours; Squamous cell cancer; Triple negative breast cancer; Ureteral neoplasms
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms METEOR-1
  • Sponsors GlaxoSmithKline; GSK

Most Recent Events

  • 12 Dec 2023 Status changed from active, no longer recruiting to completed.
  • 13 Sep 2022 Results reporting safety and efficacy data from part 2 dose expansion phase of this trial presented at the 47th European Society for Medical Oncology Congress
  • 23 Jun 2022 Planned End Date changed from 29 Apr 2025 to 31 Aug 2023.

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