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A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated, MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)

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Trial Profile

A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated, MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 25 Aug 2026

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At a glance

  • Drugs Osimertinib (Primary) ; Savolitinib (Primary) ; Carboplatin; Cisplatin; Pemetrexed
  • Indications Lung cancer; Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms SAFFRON
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 17 Aug 2026 According to a Hutchmed media release, data will be presented at a forthcoming medical meeting and shared with global regulatory authorities.
  • 17 Aug 2026 According to a Hutchmed media release, trial enrolled patients in 230 centers across 29 countries, including in North America, Europe, South America and Asia.
  • 17 Aug 2026 Results published in the Media Release

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