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A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated, MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)

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Trial Profile

A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated, MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 28 Nov 2025

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At a glance

  • Drugs Osimertinib (Primary) ; Savolitinib (Primary) ; Carboplatin; Cisplatin; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms SAFFRON
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 05 Nov 2025 According to a Hutchmed media release, the patient enrollment in the trial has been completed. And, the topline data is estimated to be reported in the first half of 2026.
  • 05 Nov 2025 Status changed from recruiting to active, no longer recruiting.
  • 03 Nov 2025 According to a Hutchmed media release, the company expect enrollment completion in late 2025.

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