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A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination With Everolimus or Pembrolizumab Versus Sunitinib Alone in First-Line Treatment of Subjects With Advanced Renal Cell Carcinoma (CLEAR)

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A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination With Everolimus or Pembrolizumab Versus Sunitinib Alone in First-Line Treatment of Subjects With Advanced Renal Cell Carcinoma (CLEAR)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 04 Nov 2024

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At a glance

  • Drugs Everolimus (Primary) ; Lenvatinib (Primary) ; Pembrolizumab (Primary) ; Sunitinib
  • Indications Renal cell carcinoma
  • Focus Registrational; Therapeutic Use
  • Acronyms CLEAR; KEYNOTE-581
  • Sponsors Eisai Co Ltd; Eisai Inc

    • Most Recent Events

    • 01 Nov 2024 Planned End Date changed from 31 Jul 2024 to 31 Mar 2026.
    • 05 Jul 2024 This trial has been Completed in Ireland, According to European Clinical Trials Database record.
    • 01 Jul 2024 Results of tumor responses for patients in the L + P arm in CLEAR, with median follow-up of ~4 yr at the final prespecified overall survival (OS) analysis, published in the European Urology

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