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A randomized phase II multicenter study with a safety run-in to assess the tolerability and efficacy of the addition of oral selinexor (KPT-330) to standard induction chemotherapy in AML and high risk myelodysplasia (MDS) (IPSS-R > 4.5) in patients aged ¡Ý 66 years .

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Trial Profile

A randomized phase II multicenter study with a safety run-in to assess the tolerability and efficacy of the addition of oral selinexor (KPT-330) to standard induction chemotherapy in AML and high risk myelodysplasia (MDS) (IPSS-R > 4.5) in patients aged ¡Ý 66 years .

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 16 Jan 2018

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At a glance

  • Drugs Selinexor (Primary) ; Cytarabine; Daunorubicin
  • Indications Acute myeloid leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions
  • Acronyms HOVON 103 AML

    • Most Recent Events

    • 12 Apr 2017 Status changed from not yet recruiting to recruiting.
    • 14 Jul 2016 New trial record

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