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DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

Trial Profile

DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 23 May 2024

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At a glance

  • Drugs Ipilimumab (Primary) ; Nivolumab (Primary)
  • Indications Adenocarcinoma; Adenoid cystic carcinoma; Adrenocortical carcinoma; Advanced breast cancer; Appendiceal cancer; Basal cell cancer; Carcinoma; Cervical cancer; Cholangiocarcinoma; Chordoma; Choriocarcinoma; Colon cancer; Colorectal cancer; Endometrial cancer; Extramammary Paget disease; Fibroma; Gallbladder cancer; Gastric cancer; Gastrointestinal cancer; Gastrointestinal stromal tumours; Gestational trophoblastic disease; Giant cell tumours; Haemangiosarcoma; Head and neck cancer; Laryngeal cancer; Lung cancer; Nerve sheath neoplasms; Neuroblastoma; Neuroendocrine tumours; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Paraganglioma; Parathyroid cancer; Pelvic cancer; Peritoneal cancer; Perivascular epithelioid cell tumours; Phaeochromocytoma; Pharyngeal neoplasms; Pituitary cancer; Prostate cancer; Rectal cancer; Renal cell carcinoma; Salivary gland cancer; Sarcoma; Seminoma; Solid tumours; Squamous cell cancer; Teratoma; Thyroid cancer; Tracheobronchial cancer; Trophoblastic tumour; Urogenital cancer; Vulvovaginal cancer
  • Focus Therapeutic Use
  • Acronyms DART
  • Most Recent Events

    • 13 Dec 2023 Planned End Date changed from 31 Oct 2024 to 1 May 2026.
    • 13 Dec 2023 Planned primary completion date changed from 31 Oct 2024 to 1 May 2026.
    • 26 Oct 2023 Results (n=4) of the GTN cohort 47 assessing efficacy of Ipilimumab plus nivolumab in chemotherapy-refractory GTN, published in the Clinical Cancer Research
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