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A Phase 1/2 Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ARQ 531 in Selected Subjects With Relapsed or Refractory Hematologic Malignancies

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Trial Profile

A Phase 1/2 Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ARQ 531 in Selected Subjects With Relapsed or Refractory Hematologic Malignancies

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 16 Nov 2024

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At a glance

  • Drugs Nemtabrutinib (Primary)
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Haematological malignancies; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Richter's syndrome; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; First in man; Proof of concept; Therapeutic Use
  • Acronyms BELLWAVE-001
  • Sponsors ArQule

    • Most Recent Events

    • 11 Nov 2024 Planned End Date changed from 12 Sep 2025 to 15 Sep 2025.
    • 11 Nov 2024 Planned primary completion date changed from 12 Sep 2025 to 15 Sep 2025.
    • 07 Mar 2024 Planned End Date changed from 13 Sep 2024 to 12 Sep 2025.

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