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An Exploratory First in Human Phase I Clinical and Pharmacokinetic Study of Intra-tumoral Administration of BO-112 in Adult Patients With Aggressive Solid Tumors, With an Extension Cohort in Combination With Anti-PD1 Treatment

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Trial Profile

An Exploratory First in Human Phase I Clinical and Pharmacokinetic Study of Intra-tumoral Administration of BO-112 in Adult Patients With Aggressive Solid Tumors, With an Extension Cohort in Combination With Anti-PD1 Treatment

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 02 Feb 2024

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At a glance

  • Drugs BO 112 (Primary) ; Nivolumab; Pembrolizumab
  • Indications Liver metastases; Solid tumours
  • Focus Adverse reactions; First in man; Proof of concept
  • Sponsors Highlight Therapeutics

    • Most Recent Events

    • 26 Jan 2024 Status changed from discontinued to completed.
    • 14 Apr 2021 According to a Highlight Therapeutics media release, data from this trial will be presented at the American Association for Cancer Research (AACR) Virtual Annual Meeting 2021, April 10-15 and May 17-21
    • 10 Apr 2021 Protocol was amended to include BO-112 in combination with anti PD-1 drugs in patients having developed progressive disease on these therapies, being treated with BO-112 plus the same checkpoint inhibitor.

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