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A Randomized, Double-blind, Placebo Controlled, 3- Part, Adaptive Design, Multicenter Study to Assess Safety, Tolerability and Efficacy of Tropifexor (LJN452) in Patients With Non-alcoholic Steatohepatitis (NASH): FLIGHT-FXR

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Trial Profile

A Randomized, Double-blind, Placebo Controlled, 3- Part, Adaptive Design, Multicenter Study to Assess Safety, Tolerability and Efficacy of Tropifexor (LJN452) in Patients With Non-alcoholic Steatohepatitis (NASH): FLIGHT-FXR

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 08 Aug 2023

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At a glance

  • Drugs Tropifexor (Primary)
  • Indications Non-alcoholic steatohepatitis
  • Focus Adverse reactions; Biomarker; Therapeutic Use
  • Acronyms FLIGHT-FXR
  • Sponsors Novartis; Novartis Pharmaceuticals

    • Most Recent Events

    • 24 Jun 2023 Results analyzing changes inliver fibrosis and individual septa parameters over time in ahomogenous, well-characterised group of patients with NASH F3 fibrosis stage; by deriving biopsy from this study, presented at the European Association for the Study of the Liver Congress 2023
    • 15 Jun 2023 According to a HistoIndex media release, post hoc analysis data from this study were recently published in Nature Medicine.
    • 15 Jun 2023 Results presented in a HistoIndex media release.

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