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Phase II study of gemcitabine, carboplatin and VELIPARIB (ABT-888) in refractory testicular germ cell cancer.

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Trial Profile

Phase II study of gemcitabine, carboplatin and VELIPARIB (ABT-888) in refractory testicular germ cell cancer.

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Carboplatin (Primary) ; Gemcitabine (Primary) ; Veliparib (Primary)
  • Indications Carcinoma; Germ cell and embryonal neoplasms; Germ cell cancer; Seminoma; Teratoma; Testicular cancer
  • Focus Proof of concept; Therapeutic Use

    • Most Recent Events

    • 08 Jun 2021 Results presented at the 57th Annual Meeting of the American Society of Clinical Oncology
    • 29 May 2021 Status changed to discontinued as 8 patients were alive and progression-free at 12 months among the first 15 patients hence the study was terminated and this study failed to achieve its primary endpoint
    • 29 May 2021 Primary endpoint 12-month PFS (Percentage of patients that will be free of disease progression according to RECIST criteria 12-months after the first administration of the treatment.)has not been met.

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