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A Phase 3, Multicenter, Prospective, Randomized, Double-blind Study of Two Treatment Regimens for Candidemia and/or Invasive Candidiasis: Intravenous Echinocandin Followed by Oral Ibrexafungerp Versus Intravenous Echinocandin Followed by Oral Fluconazole (MARIO)

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Trial Profile

A Phase 3, Multicenter, Prospective, Randomized, Double-blind Study of Two Treatment Regimens for Candidemia and/or Invasive Candidiasis: Intravenous Echinocandin Followed by Oral Ibrexafungerp Versus Intravenous Echinocandin Followed by Oral Fluconazole (MARIO)

Status: Suspended
Phase of Trial: Phase III

Latest Information Update: 22 Sep 2024

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At a glance

  • Drugs Ibrexafungerp (Primary) ; Anidulafungin; Caspofungin; Fluconazole; Micafungin; Voriconazole
  • Indications Candidaemia; Invasive candidiasis
  • Focus Registrational; Therapeutic Use
  • Acronyms MARIO
  • Sponsors SCYNEXIS
  • Most Recent Events

    • 23 Jul 2024 According to a Scynexis media release, company is looking forward to reestablish the supply chain of ibrexafungerp and restarting the Phase 3 MARIO study in invasive candidiasis.
    • 08 May 2024 According to a Scynexis media release , company has entered into certain new manufacturing agreements with third-party contract manufacturers to begin producing new batches of ibrexafungerp which will allow to lift the clinical hold and restart the Phase 3 MARIO study
    • 16 Nov 2023 According to a Scynexis media release ,status changed from recruiting to suspended.

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