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A Phase I Study of INCB024360 (Epacadostat) Alone, INCB024360 in Combination With Pembrolizumab (MK-3475), and INCB024360 and Pembrolizumab in Combination With Chemotherapy in Patients With Advanced Solid Tumors (KEYNOTE-434)

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Trial Profile

A Phase I Study of INCB024360 (Epacadostat) Alone, INCB024360 in Combination With Pembrolizumab (MK-3475), and INCB024360 and Pembrolizumab in Combination With Chemotherapy in Patients With Advanced Solid Tumors (KEYNOTE-434)

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 13 May 2022

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At a glance

  • Drugs Epacadostat (Primary) ; Pembrolizumab (Primary) ; Carboplatin; Cisplatin; Paclitaxel; Pemetrexed
  • Indications Bladder cancer; Colon cancer; Duodenal cancer; Gastric cancer; Mesothelioma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours; Urogenital cancer
  • Focus Adverse reactions
  • Acronyms KEYNOTE-434
  • Sponsors Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 01 Dec 2020 Status changed from active, no longer recruiting to completed.
    • 23 Sep 2020 Planned End Date changed from 19 Feb 2021 to 4 Dec 2020.
    • 23 Sep 2020 Planned primary completion date changed from 19 Feb 2021 to 4 Dec 2020.

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