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Phase 2 Trial of Cabozantinib (XL184), an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults With Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

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Trial Profile

Phase 2 Trial of Cabozantinib (XL184), an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults With Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 22 Sep 2025

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At a glance

  • Drugs Cabozantinib (Primary) ; Cabozantinib (Primary)
  • Indications Adenocarcinoma; Adrenal cancer; Adrenocortical carcinoma; Alveolar soft part sarcoma; Clear cell sarcoma; Ewing's sarcoma; Hepatoblastoma; Liver cancer; Nervous system neoplasms; Osteosarcoma; Renal cell carcinoma; Rhabdomyosarcoma; Soft tissue sarcoma; Solid tumours; Thyroid cancer; Wilms' tumour
  • Focus Therapeutic Use

Most Recent Events

  • 08 Jul 2025 Planned End Date changed from 25 Jun 2025 to 27 Jun 2026.
  • 25 Jul 2024 Planned End Date changed from 21 Sep 2024 to 25 Jun 2025.
  • 20 Mar 2024 Planned End Date changed from 1 Jul 2023 to 21 Sep 2024.

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