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Open-Label, Randomized Trial of Nivolumab (BMS-936558) Plus Pemetrexed/Platinum or Nivolumab Plus Ipilimumab (BMS-734016) vs Pemetrexed Plus Platinum in Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC) Subjects With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor Therapy

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Trial Profile

Open-Label, Randomized Trial of Nivolumab (BMS-936558) Plus Pemetrexed/Platinum or Nivolumab Plus Ipilimumab (BMS-734016) vs Pemetrexed Plus Platinum in Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC) Subjects With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor Therapy

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 30 Jan 2024

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At a glance

  • Drugs Ipilimumab (Primary) ; Nivolumab (Primary) ; Carboplatin; Cisplatin; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms CheckMate722
  • Sponsors Bristol-Myers Squibb

Most Recent Events

  • 23 Jan 2024 Primary endpoint has not been met. (Progression free survival (PFS) assessed by blinded independent central review (BICR)) , according to ASCO Daily News and Clinical News from the American Society of Clinical Oncology Media Release.
  • 23 Jan 2024 According to ASCO Daily News and Clinical News from the American Society of Clinical Oncology Media Release, Results presented at the 2023 ASCO Annual Meeting showed that pembrolizumab did not significantly improve PFS and OS.
  • 23 Jan 2024 Results published in ASCO Daily News and Clinical News from the American Society of Clinical Oncology Media Release

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