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A Phase 1b/2 Multicenter Study to Investigate the Safety, Efficacy and Proof of Concept (POC) of Nivolumab Monotherapy as a Sequential Therapy Following Preoperative Chemoradiotherapy Patients With Locally Advanced Resectable Rectal Cancer

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Trial Profile

A Phase 1b/2 Multicenter Study to Investigate the Safety, Efficacy and Proof of Concept (POC) of Nivolumab Monotherapy as a Sequential Therapy Following Preoperative Chemoradiotherapy Patients With Locally Advanced Resectable Rectal Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 07 Sep 2023

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At a glance

  • Drugs Ipilimumab/nivolumab (Primary) ; Nivolumab (Primary) ; Capecitabine
  • Indications Adenocarcinoma; Rectal cancer
  • Focus Proof of concept; Therapeutic Use
  • Acronyms Voltage study; VOLTAGE-A; VOLTAGE-A1

    • Most Recent Events

    • 01 Jul 2023 Results (n=25) assessing and efficacy of CRT followed by NIVO +ipilimumab (IPI) combination presented at the 25th World Congress on Gastrointestinal Cancer
    • 06 Jun 2023 Results assessing whether dynamic change of TIL in TME may predict pCR in MSS LARC presented at the 59th Annual Meeting of the American Society of Clinical Oncology
    • 21 Jan 2023 Survival outcomes and functional results of VOLTAGE-A (n=44) presented at the 2023 Gastrointestinal Cancers Symposium

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