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A Phase III, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Pertuzumab+Herceptin+Docetaxel Versus Placebo+Herceptin+Docetaxel in Previously Untreated HER2-Positive Metastatic Breast Cancer

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A Phase III, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Pertuzumab+Herceptin+Docetaxel Versus Placebo+Herceptin+Docetaxel in Previously Untreated HER2-Positive Metastatic Breast Cancer

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 13 Feb 2023

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At a glance

  • Drugs Docetaxel (Primary) ; Pertuzumab (Primary) ; Trastuzumab (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; HER2 positive breast cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms PUFFIN
  • Sponsors Roche

    • Most Recent Events

    • 01 Feb 2023 Results of final analysis assessing consistency of efficacy and safety of pertuzumab plus trastuzumab and docetaxel compared with CLEOPATRA trial published in the Breast Cancer Research and Treatment
    • 16 Feb 2021 Status changed from active, no longer recruiting to completed.
    • 12 Aug 2020 Planned End Date changed from 24 Sep 2020 to 31 Mar 2021.

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