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An adaptive multi-arm phase II trial of maintenance targeted therapy after chemotherapy in metastatic urothelial cancer

Trial Profile

An adaptive multi-arm phase II trial of maintenance targeted therapy after chemotherapy in metastatic urothelial cancer

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 30 Dec 2022

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At a glance

  • Drugs Cabozantinib (Primary) ; Enzalutamide (Primary) ; Rucaparib (Primary)
  • Indications Adenocarcinoma; Bladder cancer; Carcinoma; Squamous cell cancer; Ureteral neoplasms; Urethral cancer; Urogenital cancer
  • Focus Therapeutic Use
  • Acronyms ATLANTIS
  • Most Recent Events

    • 21 Sep 2022 Status changed from active, no longer recruiting to completed.
    • 12 Aug 2022 Primary endpoint has not been met (Progression free survival- RECIST 1.1 tumour measurements, assessed 12 weekly during trial treatment. PFS is time from randomisation until progression or death, whichever occurs first) , according to Results published in the Journal of Clinical Oncology
    • 12 Aug 2022 Results published in the Journal of Clinical Oncology
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