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Phase II clinical trial to evaluate the efficacy of FOLFIRI + aflibercept in patients with metastatic colorectal cancer previously treated with oxaliplatin with or without ACE polymorphisms

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Phase II clinical trial to evaluate the efficacy of FOLFIRI + aflibercept in patients with metastatic colorectal cancer previously treated with oxaliplatin with or without ACE polymorphisms

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 20 Oct 2022

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At a glance

  • Drugs Aflibercept (Primary) ; Fluorouracil; Folinic acid; Irinotecan
  • Indications Adenocarcinoma; Colorectal cancer
  • Focus Therapeutic Use
  • Acronyms POLAF

    • Most Recent Events

    • 13 Sep 2022 Results investigating profiles of circulating microRNAs as valuable biomarkers to build predictive models of response to treatment and survival in metastatic colorectal cancer patients treated with FOLFIRI plus aflibercept.presented at the 47th European Society for Medical Oncology Congress
    • 22 Dec 2021 Results assessing biomarker role of baseline vascular endothelial growth factor A and angiotensin-converting enzyme published in the British Journal of Cancer
    • 10 Apr 2019 Status changed from active, no longer recruiting to completed.

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