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A Phase 1/2, Open-label, Multicenter Study of the Combination of NKTR-214 and Nivolumab or the Combination of NKTR-214, Nivolumab, and Other Anti-Cancer Therapies in Patients With Select Locally Advanced or Metastatic Solid Tumor Malignancies

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Trial Profile

A Phase 1/2, Open-label, Multicenter Study of the Combination of NKTR-214 and Nivolumab or the Combination of NKTR-214, Nivolumab, and Other Anti-Cancer Therapies in Patients With Select Locally Advanced or Metastatic Solid Tumor Malignancies

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 15 Mar 2023

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At a glance

  • Drugs Bempegaldesleukin (Primary) ; Ipilimumab (Primary) ; Nivolumab (Primary) ; Carboplatin; Cisplatin; Eribulin; Paclitaxel; Pemetrexed
  • Indications Advanced breast cancer; Bladder cancer; Carcinoma; Colorectal cancer; HER2 positive breast cancer; Malignant melanoma; Non-small cell lung cancer; Renal cell carcinoma; Solid tumours; Triple negative breast cancer; Urogenital cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms PIVOT; PIVOT-02; PIVOT-04
  • Sponsors Nektar Therapeutics

    • Most Recent Events

    • 26 Sep 2022 Results assessing immunostimulatory bempegaldesleukin (BEMPEG) plus nivolumab in patients with advanced/metastatic urothelial carcinoma, published in the European Urology.
    • 22 Jun 2022 Status changed from active, no longer recruiting to completed.
    • 20 May 2022 This trial has been completed in Belgium according to European Clinical Trials Database record.

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