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A Phase II, Open Label, Randomized Study of Osimertinib (TAgrisso) alone Versus Osimertinib plus Carboplatin/Pemetrexed for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Whose Disease Has Progressed With Previous Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Whose TUmours Harbour a T790M MutatIon Within the Epidermal Growth Factor Receptor Gene

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Trial Profile

A Phase II, Open Label, Randomized Study of Osimertinib (TAgrisso) alone Versus Osimertinib plus Carboplatin/Pemetrexed for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Whose Disease Has Progressed With Previous Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Whose TUmours Harbour a T790M MutatIon Within the Epidermal Growth Factor Receptor Gene

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 16 Oct 2024

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At a glance

  • Drugs Carboplatin (Primary) ; Osimertinib (Primary) ; Pemetrexed (Primary)
  • Indications Adenocarcinoma; Non-small cell lung cancer
  • Focus Therapeutic Use
  • Acronyms TAKUMI Trial
  • Most Recent Events

    • 01 Apr 2021 Results published in the European Journal of Cancer
    • 31 Jan 2021 Primary endpoint (Progression free survival) has not been met, as per Results presented at the 2020 World Conference on Lung Cancer
    • 31 Jan 2021 Results presented at the 2020 World Conference on Lung Cancer

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