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A Phase I/II Multicenter Study Combining Guadecitabine, a DNA Methyltransferase Inhibitor, With Atezolizumab, an Immune Checkpoint Inhibitor, in Patients With Intermediate or High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

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Trial Profile

A Phase I/II Multicenter Study Combining Guadecitabine, a DNA Methyltransferase Inhibitor, With Atezolizumab, an Immune Checkpoint Inhibitor, in Patients With Intermediate or High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 17 Feb 2024

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At a glance

  • Drugs Atezolizumab (Primary) ; Guadecitabine (Primary)
  • Indications Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 09 Feb 2024 Planned End Date changed from 30 Nov 2024 to 30 Nov 2025.
    • 09 Feb 2024 Planned primary completion date changed from 30 Nov 2023 to 30 Nov 2024.
    • 12 Dec 2023 Long-term follow-up results (n=27) along with T cell programmed death-1 (PD-1) expression analysis, presented at the 65th American Society of Hematology Annual Meeting and Exposition

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