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A Phase II Study of Durvalumab (MEDI4736) (Anti-PD-L1 Antibody) in Combination With Tremelimumab (Anti-CTLA-4 Antibody) in Subjects With Advanced Rare Solid Tumors

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Trial Profile

A Phase II Study of Durvalumab (MEDI4736) (Anti-PD-L1 Antibody) in Combination With Tremelimumab (Anti-CTLA-4 Antibody) in Subjects With Advanced Rare Solid Tumors

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 10 Oct 2025

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary)
  • Indications Adenocarcinoma; Adenoid cystic carcinoma; Adrenocortical carcinoma; Advanced breast cancer; Anal cancer; Appendiceal cancer; Basal cell cancer; Carcinoma; Cervical cancer; Cholangiocarcinoma; Fallopian tube cancer; Gallbladder cancer; Liver cancer; Mesothelioma; Salivary gland cancer; Solid tumours; Thyroid cancer
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 23 Sep 2025 Status changed from recruiting to discontinued. Reason the study was stopped: poor enrollment likely due to expanded availability of immunotherapy for patients.
  • 11 Apr 2025 Planned End Date changed from 1 Jun 2027 to 1 Dec 2026.
  • 11 Apr 2025 Planned primary completion date changed from 1 Feb 2026 to 1 Dec 2026.

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