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A Phase-Ib Dose-Finding Study of the SMAC Mimetic Debio 1143 When Given in Combination With the Anti-PD-L1 Antibody Avelumab to Patients With Advanced Solid Malignancies and, in an Expansion Cohort, to Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) After Platinum-Based Therapy

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A Phase-Ib Dose-Finding Study of the SMAC Mimetic Debio 1143 When Given in Combination With the Anti-PD-L1 Antibody Avelumab to Patients With Advanced Solid Malignancies and, in an Expansion Cohort, to Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) After Platinum-Based Therapy

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 23 May 2023

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At a glance

  • Drugs Avelumab (Primary) ; Xevinapant (Primary)
  • Indications Adenocarcinoma; Mesothelioma; Non-small cell lung cancer; Ovarian cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Debiopharm

    • Most Recent Events

    • 19 Apr 2023 Results om a phase 1b dose-expansion cohort of xevinapant, a first-in-class, oral, small-molecule IAP (inhibitor of apoptosis protein) inhibitor that restores cancer cell sensitivity to apoptosis, and avelumab (anti-PD-L1) in pts with advanced NSCLC presented at the 114th Annual Meeting of the American Association for Cancer Research
    • 31 Mar 2022 Status changed from active, no longer recruiting to completed.
    • 21 Oct 2021 Planned End Date changed from 1 Feb 2022 to 1 Mar 2022.

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