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A Randomised, Double-Blind, Placebo-Controlled, First-Time-in-Human Study to Determine the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses of MT-4129 in Healthy Subjects; Including the Effect of Gender and Age on the Pharmacokinetics of a Single Dose of MT-4129 in Healthy Subjects

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Trial Profile

A Randomised, Double-Blind, Placebo-Controlled, First-Time-in-Human Study to Determine the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses of MT-4129 in Healthy Subjects; Including the Effect of Gender and Age on the Pharmacokinetics of a Single Dose of MT-4129 in Healthy Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 10 Apr 2023

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At a glance

  • Drugs Lorundrostat (Primary)
  • Indications Cardiovascular disorders; Hypertension
  • Focus Adverse reactions; First in man
  • Sponsors Mitsubishi Tanabe Pharma Corporation

    • Most Recent Events

    • 06 Mar 2023 Results of a first-in-human trial of MLS-101, a novel small molecule inhibitor with CYP11B2 selectivity presented at the 72nd Annual Scientific Session of the American College of Cardiology together with the World Heart Federation
    • 20 Feb 2023 According to a Mineralys Therapeutics media release, data from this study will be presented at the American College of Cardiologys 72nd Annual Scientific Session together with the World Congress of Cardiology (ACC.23/WCC).
    • 08 Apr 2021 Results published in the Mitsubishi Tanabe Pharma Corporation media release.

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