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A Phase 2 Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of the PI3K/mTOR Inhibitor Paxalisib (GDC-0084) Administered to Patients With Glioblastoma Characterized by Unmethylated O6-methylguanine-methyltransferase Promoter Status Following Surgical Resection and Standard Concomitant Chemoradiation Therapy With Temozolomide

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Trial Profile

A Phase 2 Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of the PI3K/mTOR Inhibitor Paxalisib (GDC-0084) Administered to Patients With Glioblastoma Characterized by Unmethylated O6-methylguanine-methyltransferase Promoter Status Following Surgical Resection and Standard Concomitant Chemoradiation Therapy With Temozolomide

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 19 Mar 2024

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At a glance

  • Drugs Paxalisib (Primary)
  • Indications Astrocytoma; Glioblastoma
  • Focus Adverse reactions
  • Sponsors Kazia Therapeutics
  • Most Recent Events

    • 08 Mar 2023 Planned End Date changed from 30 Aug 2022 to 30 Mar 2023.
    • 08 Mar 2023 Planned primary completion date changed from 30 Aug 2022 to 30 Mar 2023.
    • 09 Nov 2022 According to a Kazia Therapeutics media release, final data from the study will be presented at the upcoming annual meeting of the Society for Neuro-Oncology (SNO).
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