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A MULTICENTER, OPEN-LABEL, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND EFFICACY OF SUBCUTANEOUS OR INTRAVENOUS PF-06741086 IN SUBJECTS WITH SEVERE HEMOPHILIA

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Trial Profile

A MULTICENTER, OPEN-LABEL, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND EFFICACY OF SUBCUTANEOUS OR INTRAVENOUS PF-06741086 IN SUBJECTS WITH SEVERE HEMOPHILIA

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 29 Jan 2024

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At a glance

  • Drugs Marstacimab (Primary) ; Marstacimab (Primary)
  • Indications Haemophilia A; Haemophilia B
  • Focus Adverse reactions
  • Sponsors Pfizer

    • Most Recent Events

    • 12 Dec 2023 Results of 1b/2 study (NCT02974855), its long-term follow-up (LTFU; NCT03363321), the pivotal phase 3 BASIS study (NCT03938792), and its long-term extension (LTE; NCT05145127), presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 01 Jan 2023 Results published in the British Journal of Haematology
    • 08 Dec 2020 Results of post of analysis of data from NCT02974855 study and (biomarker data for healthy volunteers from phase 1 study NCT02531815 used as controls) assessing peak Thrombin and D-Dimer levels in subjects presented at the 62nd Annual Meeting and Exposition of the American Society of Hematology

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