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A Study of Oral LOXO-292 in Patients With Advanced Solid Tumors, Including RET Fusion-Positive Solid Tumors, Medullary Thyroid Cancer, and Other Tumors With RET Activation (LIBRETTO-001)

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Trial Profile

A Study of Oral LOXO-292 in Patients With Advanced Solid Tumors, Including RET Fusion-Positive Solid Tumors, Medullary Thyroid Cancer, and Other Tumors With RET Activation (LIBRETTO-001)

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 23 Jan 2025

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At a glance

  • Drugs Selpercatinib (Primary)
  • Indications Adenocarcinoma; Adrenal cancer; Advanced breast cancer; Carcinoid tumour; Carcinoma; Cholangiocarcinoma; Colon cancer; Large cell carcinoma; Medullary thyroid cancer; Neuroendocrine carcinoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Paraganglioma; Rectal cancer; Salivary gland cancer; Sarcoma; Skin cancer; Solid tumours; Squamous cell cancer; Thyroid cancer
  • Focus Adverse reactions; First in man; Registrational; Therapeutic Use
  • Acronyms LIBRETTO-001
  • Sponsors Loxo Oncology

    • Most Recent Events

    • 20 Jan 2025 Planned End Date changed from 28 Feb 2026 to 1 Feb 2026.
    • 20 Jan 2025 Planned primary completion date changed from 28 Feb 2025 to 1 Feb 2025.
    • 11 Nov 2024 Status changed from recruiting to active, no longer recruiting.

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