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A Phase III, Randomised, International Trial Comparing mFOLFIRINOX Triplet Chemotherapy to mFOLFOX for High-risk Stage III Colon Cancer in Adjuvant Setting

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Trial Profile

A Phase III, Randomised, International Trial Comparing mFOLFIRINOX Triplet Chemotherapy to mFOLFOX for High-risk Stage III Colon Cancer in Adjuvant Setting

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 20 Nov 2025

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At a glance

  • Drugs Irinotecan (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Adenocarcinoma; Colon cancer
  • Focus Therapeutic Use
  • Acronyms IROCAS

Most Recent Events

  • 17 Nov 2025 Status changed from active, no longer recruiting to completed.
  • 17 Sep 2025 Planned primary completion date changed from 1 Jun 2025 to 1 Jun 2026.
  • 30 Sep 2024 Planned primary completion date changed from 1 Jun 2024 to 1 Jun 2025.

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