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Open-label, Single-arm, Phase 2 Study of Initial Treatment With Elotuzumab, Carfilzomib (Kyprolis), Lenalidomide (Revlimid) and Low Dose Dexamethasone (E-KRd) in Newly Diagnosed, Multiple Myeloma Requiring Systemic Chemotherapy

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Trial Profile

Open-label, Single-arm, Phase 2 Study of Initial Treatment With Elotuzumab, Carfilzomib (Kyprolis), Lenalidomide (Revlimid) and Low Dose Dexamethasone (E-KRd) in Newly Diagnosed, Multiple Myeloma Requiring Systemic Chemotherapy

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 07 Oct 2025

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At a glance

Most Recent Events

  • 10 Sep 2025 Planned End Date changed from 1 Mar 2029 to 1 Mar 2027.
  • 12 Dec 2023 Results assessing concordance and prognostic significance of early MRD status after 4 cycles of treatment with Elotuzumab, Carfilzomib, Lenalidomide, and Dexamethasone (Elo-KRd) by next generation sequencing (NGS) in both the bone marrow and peripheral blood and by International Myeloma Working Group (IMWG) response criteria, presented at the 65th American Society of Hematology Annual Meeting and Exposition.
  • 26 Apr 2023 Planned primary completion date changed from 1 Mar 2023 to 1 Mar 2025.

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