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A Ph2 Randomized Trial to Evaluate the Safety Preliminary Efficacy and Biomarker Response of Host Directed Therapies Added to Rifabutin-modified Standard Therapy in Adults With Drug-Sensitive Smear-Positive Pulmonary TB

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A Ph2 Randomized Trial to Evaluate the Safety Preliminary Efficacy and Biomarker Response of Host Directed Therapies Added to Rifabutin-modified Standard Therapy in Adults With Drug-Sensitive Smear-Positive Pulmonary TB

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 05 Nov 2021

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At a glance

  • Drugs Auranofin (Primary) ; Colecalciferol (Primary) ; Dovramilast (Primary) ; Everolimus (Primary) ; Rifabutin
  • Indications Pulmonary tuberculosis
  • Focus Adverse reactions
  • Acronyms TBHDT

    • Most Recent Events

    • 22 Jun 2020 According to an Amgen media release, the company is interested in partnering this program with a non-government organization (NGO) for further development.
    • 09 Jan 2019 Status changed from recruiting to active, no longer recruiting.
    • 28 Jun 2018 Planned End Date changed from 1 Mar 2018 to 1 Dec 2020.

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