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A Phase 2a Randomized, Double-blind, Placebo-controlled, Multicenter Study To Evaluate The Efficacy And Safety Profile Of Pf-06651600 And Pf-06700841 In Subjects With Moderate To Severe Alopecia Areata With A Single-blind Extension Period And A Cross-over Open Label Extension Period

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Trial Profile

A Phase 2a Randomized, Double-blind, Placebo-controlled, Multicenter Study To Evaluate The Efficacy And Safety Profile Of Pf-06651600 And Pf-06700841 In Subjects With Moderate To Severe Alopecia Areata With A Single-blind Extension Period And A Cross-over Open Label Extension Period

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 13 Dec 2022

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At a glance

  • Drugs Brepocitinib (Primary) ; Ritlecitinib (Primary)
  • Indications Alopecia areata
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Pfizer

    • Most Recent Events

    • 01 Dec 2022 Results (from 5 clinical trials; NCT02310750 NCT03236493 NCT03656952 NCT02969018 NCT02974868 ) assessing Population Pharmacokinetics of Oral Brepocitinib in Healthy Volunteers and Patients published in the Clinical Pharmacology in Drug Development
    • 14 Nov 2022 Results (A cross study dose response analysis of five Phase 2 studies N=218, NCT03963401; N=212, NCT02969018; N=167, NCT02958865; N=94, NCT02974868;N=100 NCT04092452 ) assessing Pharmacologic and Clinical Rationale Brepocitinib for the Treatment of Dermatomyositis presented at the ACR Convergence 2022
    • 01 Apr 2022 Results assessing Report scores from the Alopecia Areata Symptom Impact Scale (AASIS; a patient-reported outcome tool) and explore the relationships of those scores with clinician-assessed Severity of Alopecia Tool (SALT) scores at baseline and week 24, published in the Journal of the European Academy of Dermatology and Venereology.

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