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A Randomized, Double-Blind, Placebo-Controlled Phase II Study of M2951 With a Parallel, Open-Label, Active Control Group (Tecfidera), in Patients With Relapsing Multiple Sclerosis to Evaluate Efficacy, Safety, Tolerability, Pharmacokinetics, and Biological Activity

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A Randomized, Double-Blind, Placebo-Controlled Phase II Study of M2951 With a Parallel, Open-Label, Active Control Group (Tecfidera), in Patients With Relapsing Multiple Sclerosis to Evaluate Efficacy, Safety, Tolerability, Pharmacokinetics, and Biological Activity

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 04 Jun 2024

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At a glance

  • Drugs Evobrutinib (Primary) ; Dimethyl fumarate
  • Indications Multiple sclerosis
  • Focus Proof of concept; Therapeutic Use
  • Sponsors EMD Serono; EMD Serono Research & Development Institute; Merck KGaA

    • Most Recent Events

    • 30 May 2024 This trial has been completed in Czech republic and Bulgaria, according to European Clinical Trials Database record.
    • 22 Apr 2024 Status changed from active, no longer recruiting to discontinued.
    • 01 Apr 2024 Results of the Phase II open-label extension (OLE; up to week 192 from randomisation) and a cerebrospinal fluid (CSF) sub-study, published in the Multiple Sclerosis Journal

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