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Phase III Multicenter Randomized Trial Evaluating in Patients at the Time of the Primary HIV-1 Infection, the Impact on the Viral Reservoir of a Combination Including Tenofovir/Emtricitabine and Dolutegravir or Tenofovir/Emtricitabine and Darunavir/Cobicistat

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Phase III Multicenter Randomized Trial Evaluating in Patients at the Time of the Primary HIV-1 Infection, the Impact on the Viral Reservoir of a Combination Including Tenofovir/Emtricitabine and Dolutegravir or Tenofovir/Emtricitabine and Darunavir/Cobicistat

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 04 Jul 2022

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At a glance

  • Drugs Dolutegravir (Primary) ; Emtricitabine/tenofovir disoproxil fumarate (Primary) ; Cobicistat/darunavir
  • Indications HIV-1 infections
  • Focus Therapeutic Use
  • Acronyms OPTIPRIM-2

    • Most Recent Events

    • 28 Jun 2022 Results published in the Journal of Antimicrobial Chemotherapy
    • 23 Feb 2022 Results of a sub-study to compare the kinetics of HIV-RNA and total HIV-DNA in the genital compartment in subjects receiving either tenofovir/emtricitabine/dolutegravir or tenofovir/emtricitabine/darunavir/cobicistat as a first-line combined ART (cART) at the time of PHI, published in the Journal of Antimicrobial Chemotherapy
    • 21 Jul 2021 Primary endpoint (HIV-DNA levels in the peripheral blood mononuclear cell (PBMC) at week 48) has been met, according to Results presented at the 11th International AIDS Society Conference on HIV Science.

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