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A Phase III, Open Label, Randomized Study to Assess the Efficacy and Safety of Olaparib (Lynparza) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have Homologous Recombination Repair Gene Mutations (PROfound)

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Trial Profile

A Phase III, Open Label, Randomized Study to Assess the Efficacy and Safety of Olaparib (Lynparza) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have Homologous Recombination Repair Gene Mutations (PROfound)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 21 Nov 2023

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At a glance

  • Drugs Olaparib (Primary) ; Abiraterone acetate; Enzalutamide; Prednisolone; Prednisone
  • Indications Prostate cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms PROfound
  • Sponsors AstraZeneca

    • Most Recent Events

    • 14 Nov 2023 Results of exploratory post hoc analysis of the subgroup of patients with mCRPC with BRCA alterations published in the Journal of Clinical Oncology.
    • 21 Oct 2023 This trial has been completed in Spain according European Clinical Trials Database record.
    • 09 Mar 2023 Status changed from active, no longer recruiting to completed.

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