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A Phase II Open Label Study to Evaluate the Effect of GBT440 on Hypoxemia in Subjects With Idiopathic Pulmonary Fibrosis (IPF) Who Are Using Supplemental Oxygen at Rest (ZEPHYR)

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Trial Profile

A Phase II Open Label Study to Evaluate the Effect of GBT440 on Hypoxemia in Subjects With Idiopathic Pulmonary Fibrosis (IPF) Who Are Using Supplemental Oxygen at Rest (ZEPHYR)

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 24 Aug 2020

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At a glance

  • Drugs Voxelotor (Primary)
  • Indications Hypoxaemia; Idiopathic pulmonary fibrosis
  • Focus Proof of concept; Therapeutic Use
  • Acronyms ZEPHYR
  • Sponsors Global Blood Therapeutics
  • Most Recent Events

    • 23 Oct 2017 According to a company media release, Global Blood Therapeutics has announced the discontinuation of its GBT440 program for the treatment of idiopathic pulmonary fibrosis (IPF). This decision is based on results from three proof-of-concept studies, including a Phase 1 study in healthy volunteers called Basecamp and two Phase 2a studies in patients with IPF called GBT440-006 and ZEPHYR.
    • 23 Oct 2017 Status changed from recruiting to discontinued according to a Global Blood Therapeutics media release.
    • 14 Dec 2016 New trial record
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